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Secondly, differences among populations range from slight to great, and it may be dif cult or even arbitrary to determine if populations belong to one or more than one species Conspeci c populations vary in the degree of reproductive isolation, and even in characters that ordinarily distinguish higher taxa Finally, variation among conspeci c populations forms a continuum with variation among species With respect to interpopulation differentiation as a result of pollution, three natural system studies were initiated at Miami University, Oxford, Ohio, in order to demonstrate whether a relationship existed between changes in population genetic structure and exposure to contaminants in natural systems These studies additionally investigated whether a cause-and-effect relationship existed between contaminants and sensitivity to toxicity of individuals with different genotypes.

The newest ASCCP guidelines factored age in the treatment algorithms for cervical neoplasia. For women age 20 and less, observation is a key role in the management of CIN. Low-grade lesions are very likely to resolve in this age group. Haidopoulos and colleagues described a 93% regression rate of CIN1 after 2 years in women age 16 to 20 years old.18 For this reason, if colposcopy is performed and the biopsy returns as CIN1, the recommendation is to follow the patient with yearly Pap smears for 2 years and only repeat colposcopy if cytology remains abnormal after 2 years or if it returns as greater than LSIL. With higher-grade lesions, observation is still a possible option in this younger age group. Regression of CIN 2 in adolescent and young women has been reported between 39% and 65%.19, 20 Thus, if colposcopy is satisfactory, it is reasonable to follow these patients closely with cytology and colposcopy at 6-month intervals. Limited data on regression of CIN 3 in adolescents is available. Thus, when CIN 3 is speci ed, treatment with either ablation or excision of the transformation zone is preferred.

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the probability of each of the 92 876 046 336 elements of the 21-dimensional space of this domain, only 308 conditional probabilities need to be specified An example of a conditional probability table, which is part of the factorization, is shown in Table 42 It states the conditional probabilities of the phenogroup 1 of the stated sire of a given calf conditioned on the phenogroup 1 of the true sire of the calf and whether the sire was correctly identified The numbers in this table are derived from statistical data and the experience of human domain experts The set of all 21 conditional probability tables is the quantitative part of the Bayesian network for this example After the Bayesian network is constructed, we would like to draw inferences with it.

The rst of these studies conducted by Gillespie and Guttman (1989) sampled sh and selected benthic macroinvertebrates from a stream owing through a uranium reprocessing facility in south-western Ohio Sites were sampled both above and below the production area as the stream had received a signi cant amount of radionuclide contamination from processing activities, and the level of contamination had remained high relative to upstream sites in recent years Patterns for PGM (phosphoglucomutase) in stoneroller minnows (Campostoma anomalum) were found to indicate a marked shift in allozyme frequency between the upstream and downstream sites, with the majority of change occurring over a distance of less than 500 metres Examination of genotypic proportions indicated the same pattern, with the PGM-BB genotype increasing signi cantly from upstream to downstream.

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