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and chloride is reabsorbed Table 6 2 summarizes the approximate quantitative contribution of each tubular segment to sodium reabsorption In an individual with an average salt intake, the proximal tubule reabsorbs 65% of the filtered sodium, the thin and thick ascending limbs of Henle s loop 25%, and the distal convoluted tubule and collecting-duct system most of the remaining 10%, so that the final urine contains less than 1% of the total filtered sodium As discussed in 7, reabsorption at several of these tubular sites is under physiological control by neural, hormonal, and paracrine signals, so that the exact amount of sodium excreted is homeostatically regulated Because so much sodium is filtered, even a small percentage change in reabsorption results in a relatively large change in excretion An absolutely crucial generalization is this: In all nephron segments, the essential event for active transcellular sodium reabsorption is the primary active transport of sodium from cell to interstitial fluid by the Na-KATPase pumps in the basolateral membrane These pumps keep the intracellular sodium concentration lower than in the surrounding media Because the inside of the cell is negatively charged with respect to the lumen, luminal sodium ions enter the cell passively, down their electrochemical gradient (In the proximal tubule, working in parallel with the Na-K-ATPase is a sodium-bicarbonate multiporter that actively extrudes one sodium ion in symport with three bicarbonate ions But as described in 9, this process ultimately depends on the activity of the Na-K-ATPase pumps) On examination of the luminal membrane depicted in Figure 6 1, note that there are various types of entry processes for sodium: Na-hydrogen antiporters (mostly NHE-3 isoform), Na-nutrient, Na-phosphate, or Na-sulfate symporters; and sodium channels Quantitatively, the Na-H antiporters bring in the majority of the sodium (and serve as a major site for regulating sodium reabsorption in the proximal tubule) In other chapters, you will learn other roles for particular segments besides reabsorption of sodium For example, as discussed in 5, the proximal tubule reabsorbs nutrients, and the active step in this process is often by symport with sodium across the luminal membrane. qr code generator vb net codeproject VB.NET - How to generate QR Code using VB.Net - ViscomSoft
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